nature.com/articles/s4146โฆ 2) The study investigated the genetic factors influencing antibody response to COVID-19 vaccines and clinical outcomes using data from over 350,000 vaccinated individuals in the UK.
๐๐๐ง๐๐, ๐๐ค๐ช๐ง ๐ค๐ง ๐๐๐ซ๐ ๐จ๐ฉ๐๐ฅ๐จ ๐๐ง๐ ๐ฉ๐๐ ๐๐๐๐ฃ๐๐๐จ, ๐5๐1 ๐ฏ๐ฆ๐ฆ๐ฅ๐ด, ๐ต๐ฐ ๐ฃ๐ฆ๐ค๐ฐ๐ฎ๐ฆ ๐ต๐ณ๐ข๐ฏ๐ด๐ฎ๐ช๐ด๐ด๐ช๐ฃ๐ญ๐ฆ ๐ฃ๐ฆ๐ต๐ธ๐ฆ๐ฆ๐ฏ ๐ฉ๐ถ๐ฎ๐ข๐ฏ๐ด science.org/content/articlโฆ2) From Kai Kupferschmidt's @kakape remarkable article with interviews with Tom Peacock @PeacockFlu and other experts, for the sake of simplicity, we have extracted these different steps.
cell.com/heliyon/fullteโฆ 2) This study analyzed notified respiratory infectious disease (NRID) data in Beijing's Tongzhou district from 2014-2022. It found NRID incidence increased during urbanization from 2017-2019 compared to pre-urbanization in 2014-2016 ...
sciencedirect.com/science/articlโฆ 2) This study examines cognitive impairment ('brain fog') in children post-SARS-CoV-2. At 12 months, 7% experienced brain fog, with no difference between first infection and reinfection. Persistent brain fog was reported by 2.4%.
biorxiv.org/content/10.110โฆ 2) The study evaluated 142 participants, including uninfected controls, acutely infected individuals, convalescent controls, and long COVID patients. Samples included PBMCs and plasma collected at various time points after infection.
In 2 months, 10 SARS-COV-2 variants + 9 others pathogens detected in wastewater from aircraft and airport terminals at Singapore Changi Airport, Jan-Feb 2023 medrxiv.org/content/10.110โฆ
2) The study investigated the feasibility of monitoring SARS-CoV-2 and other pathogens in wastewater from aircraft and airport terminals at Singapore Changi Airport between Jan-Feb 2023.
SARS-CoV-2 and variants were detected in wastewater from both aircraft and airport terminals.
โถ๏ธ 104 PARTICIPANTS TESTED POSITIVE
โถ๏ธ 36 with NO SYMPTOMS <30 days
โถ๏ธ 68 with SYMPTOMS > 91 DAYS
incl.
โถ๏ธ 60 with SYMPTOMS from 231 to 680 DAYS !!! ๐ฑ academic.oup.com/ooim/article/5โฆ 2) This study investigates post-acute sequelae of SARS-CoV-2 (PASC) in 68 healthcare workers in South Africa with persistent COVID-19 symptoms beyond 91 days. The most common symptoms were headaches, cough, fatigue, muscle pain and shortness of breath.
They are a commonly used cell line in scientific research, particularly in the field of neuroscience. These cells are derived from a human neuroblastoma, a type of cancer that forms in nerve tissue.
nature.com/articles/s4139โฆ 2) SARS-CoV-2 infection aberrantly elevates mitochondrial bioenergetics and induces mitochondrial elongation during the early stages of infection in human cells. This promotes ATP generation to support robust viral replication.
Thanks to @DavidJoffe64
for this study๐ nature.com/articles/s4140โฆ 2) The study compared outcomes of different community-acquired respiratory virus (CARV) lower respiratory tract disease (LRTD) episodes in 235 adult allogeneic stem cell transplantation (allo-SCT) recipients between 2013-2023.
2) Scarlet fever is caused by certain strains of S. pyogenes that produce a toxin called streptococcal pyrogenic exotoxin A.
The M1 strain that caused the recent upsurge is notable for having increased expression of the SpeA toxin due to mutations in the phage that produces it.
Researchers in Texas recently discovered the H5N1 avian influenza virus in wastewater samples ... medrxiv.org/content/10.110โฆ 2) ...from nine major cities over a two month period in 2024. This was unexpected as the virus had not previously been found in over 1,300 wastewater tests.
By sequencing the entire virome found in wastewater, the team was able to identify genetic sequences ...
(๐ธ๐ช๐ต๐ฉ ๐ข๐ฎ๐ข๐ป๐ช๐ฏ๐จ ๐ท๐ช๐ด๐ถ๐ข๐ญ๐ช๐ด๐ข๐ต๐ช๐ฐ๐ฏ๐ด !) cell.com/trends/geneticโฆ 2) For this 15th study, summarized, illustrated and, posted in less than 24 hours ! (a new personal record), we decided to start, with some visualizations of Cryo-electron microscopy (cryo-EM) tomographic 3D reconstructions of RNA replication organelles ๐ค
cell.com/cell-reports-mโฆ 2) BA.2.86 is a recently emerged sublineage of SARS-CoV-2 Omicron that has acquired many mutations, especially in the spike protein. This raised concerns about its potential for immune escape.
Thanks to @1goodtern who alerted about this topic in UK, this disease is back.
๐๐๐๐๐ ๐๐ฃ๐ ๐๐๐ ? 2) Back, not only in UK but also in Europe. 25 000 cases for the all year 2023, 32 000 just from January to March 2024 !!!
๐๐ฉ๐ฆ ๐ฃ๐ข๐ค๐ต๐ฆ๐ณ๐ช๐ฐ๐ฑ๐ฉ๐ข๐จ๐ฆ ๐ฃ๐ฆ๐ฉ๐ข๐ท๐ช๐ฐ๐ณ ๐ฐ๐ง ๐๐๐๐-๐๐๐-2 ?
From @carlobrogna1 and team mdpi.com/2076-2607/12/4โฆ 2) The authors argue that SARS-CoV-2 and potentially other RNA viruses like poliovirus exhibit bacteriophage behavior, meaning they infect and replicate within bacteria rather than directly infecting human cells.
frontiersin.org/journals/immunโฆ 2) Platelets play an important role in both hemostasis and immune response. During the COVID-19 pandemic, abnormal clotting and low platelet counts in severe cases have been observed. While platelets are undoubtedly activated during COVID-19 infection, the specific mechanisms..
tandfonline.com/doi/full/10.10โฆ 2) mRNA vaccines show promise but require encapsulation by lipid nanoparticles (LNPs) to protect the mRNA and enable delivery. The average particle size of LNPs is a critical factor, as it influences stability, efficacy, and safety.
cosmosmagazine.com/science/biologโฆ 2) Viruses are responsible for deadly diseases but are considered non-living because they lack the biological machinery to multiply through cellular division, and don't have a metabolism. The definition of life is not universal, but viruses don't meet the criteria for being alive
(๐งต 2 ๐ด๐ต๐ถ๐ฅ๐ช๐ฆ๐ด ๐ข๐ฏ๐ฅ 1 ๐ข๐ณ๐ต๐ช๐ค๐ญ๐ฆ ๐ฐ๐ฏ ๐ต๐ฉ๐ช๐ด ๐ต๐ฐ๐ฑ๐ช๐ค) gut.bmj.com/content/71/6/1โฆ 2) In this first study, researchers examined the relationship between gut microbiota composition and immune responses/adverse events in 138 individuals who received either the CoronaVac inactivated vaccine or the BNT162b2 mRNA vaccine against COVID-19.